Fundamental Research

Electrospinning is an increasingly popular technique in fundamental biomedical and tissue engineering research to produce nano-fibrous, non-woven scaffolds. The interest in these electrospun scaffolds is based on their potential to mimic the natural environment of cells in the body – the extracellular matrix (ECM) – in function, architectures and size scales. The underlying reasons for this potential, are the tuneability of the spinning process and the abundance of spinnable materials. Since each step in the process can be individually finetuned, the possibilities of end products are infinite.

A cascade of events is initiated when changing any of the spinning parameters. Alterations in the process lead to altered fiber and scaffold properties, such as mechanical properties or architecture. In their place, altered fiber and scaffold properties lead to altered biological responses, such as cell infiltration, proliferation and differentiation or ECM deposition and remodelling. With this in mind, carefully finetuning the spinning process in order to obtain the desired fiber and scaffold properties and hence biological responses, is key. To ensure reproducible research outcomes, unintentional spinning process deviations are to be prevented.

IME specializes in reliable electrospinning research equipment that ensures the reproducibility of it’s fiber-based products. Read more about our state-of-the-art research equipment and find out about the publications made with it.