Electrospraying is like electrospinning a voltage driven material processing technology. Electrospraying produces droplets or a fine aerosol of particles with a size in the tens of nanometers up to few micrometers. Much like electrospinning, electrospraying was already discovered more than a century ago. Thanks to Fenn’s Nobel Prize in 2002, for developing electrospraying as a soft ionization method for large biomolecules, this method gained a lot of interest on top of its prevailing use in Mass spectrometry.

Electrospraying is performed with the same equipment as electrospinning. The basic difference between these two processes is the solution viscosity. Due to the lower viscosity the jet breaks up into small, charged droplets, which are dispersed radially and solidify as the solvents evaporates. As for electrospinning, parameters such as flow rate, needle-collector distance and voltage can be used to tune the size of nanoparticles.

This process uses the same modules and offers the same flexibility as electrospinning and electrospraying is known as a convenient and scalable particle synthesis with high encapsulation efficiency1.

An application for this room temperature technique is to produce stable nanoparticles based on natural polymers which maintain their bioactivity1. So e.g. combining active ingredients into secondary matrix in one step, to for example incorporate poorly soluble pharmaceutical compounds into a solid dispersion to improve their body uptake2.


  1. Sridhar, R. & Ramakrishna, S. (2013). Electrosprayed nanoparticles for drug delivery and pharmaceutical applications. Biomatter 3 (3).DOI:  10.4161/biom.24281
  1. Smeets, A., Clasen, C. & Van den Mooter, G. Electrospraying of polymer solutions: Study of formulation and process parameters. Eur. J. Pharm. Biopharm. 119, 114–124 (2017). DOI: 10.1016/j.ejpb.2017.06.010

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