Electrospinning drug loaded fibers on ice to mimic cartilage ECM

03 April 2017

Electrospinning drug loaded fibers in combination with cell-laden hydrogels shows to be a very promising approach for cartilage tissue engineering. Our customer from ETH Z├╝rich and a team from EMPA filled up the large pores gained by electrospinning on a low temperature drum with cells suspended in a hydrogel to create a biomimetic of cartilage. The drug loaded electrospun fiber had a dual purpose; mechanically stabilizing the hydrogels and to release the drug to protect the cells from an inflammatory insult. This combination allowed these chondrogenic biomometic tissue contructs to survive for more than 3 weeks in-vivo.

Read more about this publication: A Bioinspired Ultraporous Nanofiber-Hydrogel Mimic of the Cartilage Extracellular Matrix. DOI: 10.1002/adhm.201600867

IME Technologies positions itself as the leading partner for the medical device industry when it becomes to developing medical implants for regenerative medicine applications. IME Technologies has developed state-of-the-art electrospinning equipment to facilitate the research, development and manufacturing of electrospun scaffolds, implants and medical devices. Our platform excels in terms of reproducibility and scalability and the GMP compliance make them the obvious choice for the medical device industry.

Electrospinning is a key enabling technology for addressing the needs in the regenerative medicine market.